Incumbent John Cornyn (R) defeated M.J. Hegar (D), David B. Collins (G), Kerry McKennon (L), and Ricardo Turullols-Bonilla (I) in the general election for U.S. Senate in Texas. Cornyn was first elected in 2002. 

The last Democrat to win a U.S. Senate election in Texas was Lloyd Bentsen (D) in 1988. Democrats last won a statewide election in Texas in 1994.

Leading up to the 2020 elections, Republicans had a 53-47 majority in the Senate. Thirty-five of 100 U.S. Senate seats are up for election this year. Of the 35 seats up, 23 are held by Republicans and 12 by Democrats, giving Republicans greater partisan risk this year. Democrats need to win a net four seats to win an outright majority in the chamber.