Incumbent Juan Ciscomani (R), JoAnna Mendoza (D), and Jereme Peters (L) are running in the general election for Arizona's 6th Congressional District on November 3, 2026.

Politico's Samuel Benson said, "[Arizona's 6th] district is considered one of the most competitive on the map this year, and Democrats have carried it in recent statewide elections. Democratic Sen. Ruben Gallego won the district in 2024, as did Democratic Gov. Katie Hobbs and Sen. Mark Kelly in 2022." Ciscomani won 50.7%–49.2% in 2022 and 50.0%–47.5% in 2024. That year, Donald Trump (R) defeated Kamala Harris (D) 49.8%–49.1% in the 6th District. As of July 2026, major election forecasters rated the general election Toss-up or Lean Democratic.

Ciscomani was first elected to the House in 2022. He earlier worked at the University of Arizona, the Tucson Hispanic Chamber of Commerce, and for Gov. Doug Ducey (R-Ariz.). In a press release, Ciscomani said, "Mendoza is far more aligned with the priorities of the extreme left than the concerns of everyday Arizonans struggling with rising costs. ... Mendoza has also called for ending tax cuts, tax credits, and sales tax exemptions that help Arizona families keep more of what they earn."

Mendoza is a 20-year veteran of the U.S. Navy and U.S. Marine Corps. She worked as a staffer for U.S. Rep. Tom O'Halleran (D), a policy analyst, and a nonprofit leader. Mendoza ran unsuccessfully for the Arizona Senate in 2020. In a statement, Mendoza said, "Spineless Members of Congress like Juan Ciscomani continue to vote to drive up the costs of groceries, energy, and gas, put healthcare out of reach, and make our communities less safe. Now more than ever, our families deserve servant leadership in Congress."

As of July 1, 2026, Ciscomani had raised $6.17 million and Mendoza had raised $7.35 million.

The outcome of this race will affect the partisan balance of the U.S. House of Representatives in the 120th Congress. All 435 U.S. House districts are up for election.

Currently, Republicans have a 219-212 majority with four vacancies in the chamber.