Jessica Killin (D) defeated incumbent Jeff Crank (R) and three other candidates in the general election for Colorado's 5th Congressional District on November 3, 2026.

Heading into the election, no Democrat had won election to represent the 5th District since its creation in 1972. The Denver Post's Elizabeth Hernandez said, "[N]ational Democrats have marked the race to unseat Republican U.S. Rep. Jeff Crank as one to watch [because of] demographic shifts, falling approval for President Donald Trump and fired-up liberal voters." Crank won the 2024 election 54.7%–40.9%, while Trump won the district 53.2%–44.1% over Kamala Harris (D). As of November 2026, major election forecasters rated the general election Likely Republican, Toss-up, or Lean Democratic.

Killin was, as of the 2026 election, a U.S. Army veteran, former executive with the United Services Automobile Association (USAA), and former political staffer to Reps. Donna Shalala (D-Fla.), Carolyn Maloney (D-N.Y.), and Marie Gluesenkamp Perez (D-Wash.), as well as Second Gentleman Doug Emhoff (D). In a statement, Killin said, "I'm running for Congress because Washington needs leaders who are focused on actually getting things done— not partisan name-calling and bitter culture wars. The Pikes Peak Region deserves results-oriented, competent leadership. Instead, Jeff Crank has let his constituents down, voting to kick thousands off healthcare while raising the national debt by trillions."

Crank was elected in 2024. He earlier worked as a radio show host, an executive at Americans for Prosperity, and a staffer to U.S. Rep. Joel Hefley (R-Colo.). In an interview with Colorado Politics, Crank said, "The question, and I think this will be one in this race, is, does this community just want somebody who’s anti-Trump to fight and push back on Trump? Or do they want somebody who, no matter who the president is, whether it’s Joe Biden or Donald Trump, is going to go try and work to represent this community and get the best things for this community that they can?"

Christopher Mitchell (American Constitution Party), Mark Elworth Jr. (L), and Steven Fuller (Unaffiliated) also ran.

As of November 2, 2026, Crank had raised $2.87 million and Killin had raised $5.59 million.

The outcome of this race affected the partisan balance of the U.S. House of Representatives in the 120th Congress. All 435 U.S. House districts were up for election.

At the time of the election, Republicans had a 219-214 majority with two vacancies in the U.S. House.