Incumbent Fred Upton (R) defeated Jon Hoadley (D), John Lawrence (G), and Jeff DePoy (L) in Michigan’s 6th Congressional District. Based on unofficial returns, Upton received 59 percent of the vote and Hoadley received 38 percent. Upton was first elected in 1986. 

In 2018, Upton defeated Matt Longjohn (D) 50.2% to 45.7%. That was Upton’s narrowest general election margin of victory to date; he had previously defeated Democratic challengers by an average of 29 percentage points.

In the 2016 presidential election, President Donald Trump (R) defeated Hillary Clinton (D) 51% to 43% in Michigan’s 6th. The district contains one Pivot County—Van Buren County—that voted for Barack Obama (D) in 2008 and 2012 and Trump in 2016

Heading into the election, Democrats had a 232-197 majority in the House. Republicans needed to win a net 21 seats to win control of the chamber.