Incumbent Ashley B. Moody (R) defeated Angie Nixon (D) and Neil Gillespie (No Party Affiliation) in the special election for U.S. Senate in Florida on November 3, 2026.

Moody was elected to serve the remainder of the term Marco Rubio (R) was elected to in 2022, which expires in January 2029. Rubio resigned on January 20, 2025, after the U.S. Senate confirmed him as U.S. Secretary of State under President Donald Trump (R). Governor Ron DeSantis (R) appointed Moody as Rubio's interim successor on January 21, 2025.

Rubio was re-elected 57.7%–41.3% in 2022. In 2024, U.S. Sen. Rick Scott (R) was re-elected 55.6%–42.8% and Trump defeated Kamala Harris (D) 56.1%–43.0% in Florida. The most recent Democrat to win a statewide election in Florida as of 2026 was Nikki Fried (D), who won the 2018 election for agriculture commissioner 50.0%–50.0%. The most recent Democrat elected to the U.S. Senate from Florida as of 2026 was Bill Nelson (D) in 2012. As of November 2026, major election forecasters rated the general election Solid Republican or Likely Republican.

Before her appointment to the Senate, Moody served as Florida Attorney General from 2019 to 2025 and as an elected judge on Florida's 13th Judicial Circuit Court from 2007 to 2017. She earlier worked as a law professor and federal prosecutor. Moody's campaign website said, "Throughout her tenure as Attorney General, Ashley earned a reputation as a fierce leader in the fight against unelected bureaucrats in Washington who sought to undermine Florida’s policies. She has also been a national leader in protecting religious freedom and the sanctity of life. ... As U.S. Senator, Ashley continues her mission to uphold conservative values, strengthen national security, and fight for Floridians."

Nixon was elected to the Florida House of Representatives in 2022. She earlier worked as an organizer, activist, and bookstore owner. Nixon completed Ballotpedia's Candidate Connection survey. In her survey response, Nixon wrote, "Public policy first and foremost should work for people and, right now, that’s not the case. People are struggling to put food on their table and keep a roof over their head. Meanwhile, politicians in Washington are looking out for corporations. I’m running for U.S. Senate to make sure the government works for us, not against us."

As of November 2, 2026, Moody had raised $14.5 million and Nixon had raised $11.3 million. As of the same date, satellite groups had spent a combined $23.2 million supporting and opposing Moody and Nixon. This figure included $10.4 million spent to oppose Nixon, $5.35 million spent to support Nixon, $3.94 million spent to support Moody, and $3.56 million spent to oppose Moody.

Moody's final result of 50.9% was 6.8% lower than Rubio's (R) 57.7% in 2022. Nixon's 48.0% was 6.7% higher than Val Demings' (D) 41.3% in 2022.

The outcome of this race affected the partisan balance of the U.S. Senate in the 120th Congress. Thirty-three of the 100 U.S. Senate seats were up for election, and another two seats were up for special election. Democrats held 13 of the seats up for election, and Republicans held 22.