Trudy Busch Valentine won the Democratic primary for U.S. Senate in Missouri on August 2, 2022. She received 43.2% of the vote based on unofficial returns. Lucas Kunce came in second place with 38.4%. Nine other candidates also ran in the primary with no one receiving more than 5%.

Busch Valentine is a former nurse and heiress of the Anheuser-Busch brewing company. She was endorsed by a former U.S. senator, one current and one former U.S. representative, the current and two most recent mayors of St. Louis, and 12 state legislators.

Kunce works at the American Economic Liberties Project and served in the United States Marine Corps. He was endorsed by U.S. Sen. Bernie Sanders (I-Vt.), a former U.S. representative, Pennsylvania Lt. Gov. John Fetterman, the St. Louis Post-Dispatch, and three state legislators.

Busch Valentine will face Attorney General Eric Schmitt (R) in the November 8 general election. Three independent race forecasters rate the race as either Likely Republican or Solid Republican. Donald Trump won the state in the 2020 presidential election with 56.8% of the vote.