Initiative 81 declares that police shall treat the non-commercial cultivation, distribution, possession, and use of entheogenic plants and fungi as among the lowest law enforcement priorities. Examples of decriminalized substances include psilocybin mushrooms, also known as magic mushrooms or shrooms, peyote, and iboga. This makes D.C. the fifth city after Oakland and Santa Cruz, California; Denver, Colorado; and Ann Arbor, Michigan, to decriminalize psilocybin mushrooms.

Oregon is the first state to create a program to legalize psilocybin services after approving Measure 109 in the 2020 election.