U.S. Reps. Ann Wagner (District 2), Blaine Luetkemeyer (District 3), Sam Graves (District 6), and Jason Smith (District 8) face primary challengers this election cycle. In the 2020 election cycle, two incumbents (Wagner and Smith) were unopposed in Republican primaries. 

Luetkemeyer and Graves face the most primary challengers at four apiece. Wagner faces four challengers, and Smith has one challenger. These primaries will take place on Aug. 2, with the winners advancing to general elections on Nov. 8.

There are at least two Republican candidates on the ballot across all nine of Missouri’s congressional races this year. In the U.S. Senate primary, 21 candidates will compete for the party nomination. Eight candidates each are running in both the District 4 and District 7 primaries where there is no incumbent seeking re-election. 

Incumbents are not seeking re-election in three of the races. Roy Blunt (R) is retiring from the U.S. Senate, while Vicky Hartzler (R-District 4) and Billy Long (R-District 7) are both running for U.S. Senate.

One U.S. Senate seat and eight seats in the U.S. House of Representatives are up for election in 2022. Democrats currently hold two of the House seats and Republicans currently hold both Senate seats and six House seats.